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How to take sodium oxybate

Before you start this treatment, read the manufacturer’s printed information leaflet from inside your pack. The leaflet will give you more information about sodium oxybate and a full list of side-effects which you may experience from taking it.
Take sodium oxybate exactly as your doctor tells you to. When starting this treatment your doctor will give you a small dose and then gradually increase it. This allows your doctor to make sure that you have the dose that helps your condition and avoids any unwanted symptoms. It is taken in two doses – the first dose taken as you go to bed, and the second dose 2½-4 hours later. You should prepare both doses before you retire to bed, and you may need to set an alarm to make sure you wake up to take the second dose.
Food interferes with how much of this medicine is absorbed by your body, so it is important that you take sodium oxybate well after eating any food. Most doctors will recomend that it is taken at a set time each evening, at least 2-3 hours after your evening meal.
Mix each of your doses with water (see below).
If you forget to take the first dose, take it as soon as you remember and then take the second dose 2½-4 hours later. If you forget to take the second dose, do not take it when you remember but instead skip the dose completely and do not take any more until the following evening. Do not take two doses together to make up for a forgotten dose.
Instructions for using Xyrem® Oral Solution
Remove the bottle cap and the foil seal. Push the plastic adaptor into the top of the open bottle.
Insert the syringe into the adapter.
Keeping the bottle upright, gently pull out the plunger of the syringe so that the solution fills the syringe to the mark which corresponds to your dose.
Remove the syringe from the bottle, and empty the liquid from the syringe into the dosing cup.
Repeat steps 2-4 to prepare your second dose.
Add 60 ml of water (about four tablespoons) to both dosing cups, and then close both of the cups with the locking caps provided.
Replace the cap on the bottle of Xyrem® Oral Solution, leaving the adapter in place. Wash the syringe with water.

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Before taking sodium oxybate

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sodium oxybate it is important that your doctor or pharmacist knows:

If you are pregnant, trying for a baby or breast-feeding.
If you have epilepsy.
If you have any problems with your heart or your breathing, or if you have high blood pressure.
If you have problems with your liver or kidneys.
If you have ever had a depressive illness.
If you have ever had a drug addiction problem.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.

Warnings and Precautions :
It is a habit forming drug. It is called the street drug of abuse. Therefore it is available only through a special program and the treatment can be carried out only under strict monitoring by a doctor.
Avoid drinking alcohol, driving and operating machinery.
Caution should be exercised in patients with history of liver disease, heart disease, high blood pressure, or kidney disease , history of alcohol or drug abuse, asthma, emphysema, or bronchitis, sleep apnea, mental illness such as bipolar disorder or schizophrenia.

Side Effects :

Most Common- Headache, nausea, dizziness, throat pain, drowsiness, vomiting, and urinary incontinence.

Eye and ENT- Ringing in the ear, blurred vision.

Gastrointestinal- Abdominal pain, Diarrhea, Indigestion, Nausea and Vomiting.

General- Lethargy, pain.

Musculoskeletal- Back pain.

Central Nervous System- Disturbance in attention, Dizziness, Headache, Confusional state, Depression, Sleep disorder, Sleep walking.

Storage Conditions :
Store as per instructions and keep out of reach of children.

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